There are several problems with ASP.NET MVC application when
deployed on IIS 6.0:

Extensionless URLs give 404 unless some URL Rewrite module is
used or wildcard mapping is enabled
IIS 6.0 built-in compression does not work for dynamic
requests. As a result, ASP.NET pages are served uncompressed
resulting in poor site load speed.
Mapping wildcard extension to ASP.NET introduces the following
problems:

Slow performance [...]